Friday, November 11, 2011

Practice exam! 2005

Hi, just a quick question I tried to attemp part B) of one of the questions from the immunology section! Following on from the cardinal signs of inflammation (which was fine) I know that histamine, complementm kinins and prostaglandins are all chemical mediators.. I've researched the ones I dont know well at all.. But still having trouble putting it in context/answer.. has anyone else done this question and could help me out?
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  1. MirelaNovember 13, 2011 at 12:52 PM

    Hi Olivia,
    Not sure if you were able to come up with an answer to this yet. I am having same difficulty. So far I got
    Histamine - granules of mast cells and basophils - promotes vasodilation, increase permeability of local capillaries, promoting exudate formation
    Kinins - effects are same as for histamine, induce chemotaxis of leucocytes, induce pain
    Hope this covers it.
    Prostaglandins - effects are same as for histamine, induce chemotaxis of neutrophils, induce pain
    Complement - plasma proteins - once activated release chemical mediators that amplify inflammatory process

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